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Therneau, R

So, in summary: FOXO4-DRI appears to represent the next-generation senolytic, offering improved specificity, but it is still earlier stage than many small-molecule senolytics or repurposed drug combinations

Notably, incubation of AX with L-cysteine (with the nonprotected-amino group) did not afford DKP, but mainly, the product corresponding to the aminolysis of the -lactam ring, which remained conjugated to the amino group of cysteine through an amide bond ( Figure S8 )