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[DOI] [PubMed] [Google Scholar] 73.Greco E., Russo G., Giandalia A., Viazzi F., Pontremoli R., De Cosmo S

Butyrate supports emotional balance through multiple pathways: [24] Neurotransmitter Production : Supports the synthesis and release of GABA, the brain's primary calming neurotransmitter HPA Axis Regulation : Helps modulate the hypothalamic-pituitary-adrenal axis, your body's stress response system BDNF Expression : Increases brain-derived neurotrophic factor, crucial for neuronal health and mood regulation Serotonin Signaling : Influences serotonin production in enterochromaffin cells of the gut Animal studies have demonstrated mood-boosting effects from butyrate administration, though human clinical data remains limited

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They can recommend how often you should take it and may suggest cycling: either taking breaks from the supplement or temporarily swapping it with another