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Under the stress of amino acid deprivation, the expression of SLC7A11 is largely mediated by ATF4 (Sato et al., 2004)

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CBT: Cognitive behavior therapy Anxiety disorders Between one-third and one-half of individuals with BD have a comorbid anxiety disorder, a finding also supported by Indian data, though rates vary.[184,185,186] Data from Asia and elsewhere consistently show that comorbid anxiety disorder worsens the course and outcomes of BD, with prolonged symptomatic periods, more depressive episodes, higher suicidality, poorer psychosocial functioning, and reduced treatment response