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Lillys Zepbound, approved in November 2023 as the Indiana-based drug giants answer to Novo Nordisks Wegovy, showed 21% average weight loss after 72 weeks for its highest dose in its Phase 3 trial, and a mid-stage study of another Lilly experimental medicine, called retatrutide, showed 24% weight loss after just 48 weeks

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(Gastroenterology, 2008) reported that it is taken up through the di- and tripeptide transporter PepT1, which is expressed in the small intestine and induced in the colon during inflammation, with reduced NF-B activation in human epithelial and immune cell lines, and Viennois et al