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van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH

Chem Rev (2001) 101:2381411

In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

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