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The first system focuses on monitoring substrate consumption by measuring either GSH depletion or ROOH utilization at regular time intervals

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

These observations highlight the suitability of the HepG2 model to study these events and the necessity to define cellular sensors and signaling cascades involved in the NFT-induced increase of glutathione levels