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COMBINATION OR SEQUENTIAL THERAPY Neurostimulation Transcutaneous electrical nerve stimulation (TENS) is a noninvasive method of neuromodulation using cutaneous adhesive electrodes to apply pulsed electrical stimulation that stimulates A-beta fibers with the goal of indirectly inhibiting nociceptive transmission in the spinal cord dorsal horn [87-89]

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In pulmonary arterial hypertension (PAH), specific studies using monocrotaline (MCT)-induced PAH models suggest that liraglutide acts through the NO/sGC/cGMP pathway, increasing NO release, activating soluble guanylate cyclase (sGC), and enhancing cyclic guanosine monophosphate (cGMP) synthesis

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