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1 Introduction Methotrexate (MTX) is a dihydrofolate reductase inhibitor and chemotherapeutic agent with proven efficiency against cancers and rheumatoid arthritis ( Oxidative stress, which results from the excess production of reactive oxygen species (ROS), has a fundamental role in the MTX-associated toxicities pathogenesis ( The endoplasmic reticulum (ER) is a fundamental cellular organelle responsible for the newly synthesized proteins folding into their final 3-dimentional structures, post-translational modification, transportation, and quality control ( Apoptosis is essential in cellular homeostasis maintenance and is activated during adverse conditions (Figure 1)
The PCA score plot showed that the first principal component (PC1) and second principal component (PC2) accounted for 36% and 24.3% of the total variance, respectively (Fig
BPC-157 has demonstrated analgesic (pain-relieving) effects in several studies
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