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Management: Limit use to 46 week cycles with at least equal time off Consider using GH peptides like GHRP2 or CJC1295 during off cycles to maintain baseline IGF-1 activity Risk of Unwanted Growth (Organs, Gut, Tumors) Long-term, excessive IGF1 can theoretically increase the risk of visceral organ growth , insulin resistance , or even tumor promotion , due to its role in cell proliferation

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Funding This work was supported by grants from the 12th Undergraduate Training Program for Innovation of Shanghai Jiao Tong University School of Medicine (1218033), from National Natural Science Foundation of China (81672322, 81972210, and 31601118)