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Cole, H

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

Mild side effects can include rash, mild nausea, and transient changes in blood pressure

The non-significant beneficial effect of GSH supplementation on oxidative stress and antioxidant capacities might be due to inadequate selenium status in our cirrhosis patients