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Mechanisms of pyrethroid resistance in the dengue mosquito vector, Aedes aegypti : target site insensitivity, penetration, and metabolism

Although the addition of the membrane context greatly increases the realism of the system compared with previous membrane-free structural analyses, it is of course possible that yet further changes will be seen once it becomes feasible to reach atomistic resolution in situ and determine the structure as found on lysosomes in cells

Weight loss proved to be the most common concern, preventing the trial completion of 1 patient, and proved fully reversible on cessation of the drug in the open trial