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While insomnia isnt a listed side effect of the drug, a minority of people report difficulty falling or staying asleep while taking the medication for weight loss

This could lead to Vit B12 depletion and transforms SAM into S-adenosyl-homocysteine and then into Hcy, the latter serving as a marker for methylation capacity (Mller and Riederer 2023)

Clinical trials have shown that semaglutide can lead to significant weight loss in people with type 2 diabetes when combined with diet and exercise

Understanding this physiological reality and planning ahead makes the difference between temporary weight loss and lasting metabolic change