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4.2 Cysteine and homocysteine in kidney diseases As evidenced by several studies, the kidneys play a pivotal role in the regulation of the methionine cycle, exerting a direct influence on alterations in the concentrations of homocysteine, cysteine, S-adenosylmethionine, S-adenosylhomocysteine, and the SAH/SAM ratio [56, 57]