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Although this difference in the gut microbiome is in part driven by standard of therapy used in treatment of cirrhosis and HE (such as oral antibiotics, NADs, and acid suppressants) which can affect the gut microbiome composition, 33 cross-sectional data of stool metagenomics have revealed that certain metagenomic species are overexpressed or underexpressed in decompensated compared to compensated cirrhosis

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