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For those paying out of pocket, certain doses of Zepbound are available in single-dose vials, which may be more affordable than the pen

Ultimately, that could inform more personalized treatment strategies. The findings also underscore the importance of studying drug effects over extended periods

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Another animal study showed that inhibition of TMAO formation can upregulate the host hepatic bile acid synthetic enzyme CYP7A1 and alter the expression of hepatic genes critical for bile acid feedback regulation, thus preventing diet-driven hepatic cholesterol accumulation (Pathak et al., 2020)