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Finally, the impurity sequences were assessed for their potential to increase the immunogenicity of the drug product due to the presence of new epitopes predicted in the impurity but not in the API ( This emphasis on the creation of new epitopes that are not conserved with the API relates to the additive effect of effector T-cell responses to these epitopes

The result is a program that integrates the peptide appropriately and sets realistic expectations about what the current research does and does not show

For athletes training at high intensities who may have increased nutrient demands, this efficiency gap becomes particularly relevant

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