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Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity

This sustained decline culminates in severe, long-lasting consequences for both overall health and the quality of life (6)

A number of these outcomes will probably be permanent

Ive had patients come in with B12 levels of 201 pg/ml with the word normal scribbled across it by the doctor