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Without resistance training, creatine is unlikely to have a meaningful effect on muscle retention or body composition

For instance, 30% CR confers additional life extension in Ames dwarf mice (Bartke, 2011), but has no additional effect on longevity in male Ghr/ mice, and only a modest reduction of late-life mortality in Ghr/ females (Bonkowski et al., 2006)

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Finally, the emergence and termination of some forms of plasticity during critical periods has been generally addressed in quiescent states out of considering a more physiological scenario where external inputs such as ongoing neuronal networks oscillations command the sign of plasticity as it may occurs in vivo