Although exciting, these data are preliminary and there is a need to learn more
Understanding Tirzepatide: What It Is: Dual GIP/GLP-1 receptor agonist First-in-class medication combining two mechanisms Activates both GIP and GLP-1 receptors Produces superior weight loss to single-agonist medications Half-life of approximately 5 days (allows once-weekly dosing) Brand Names: Zepbound: Indication: Chronic weight management in adults with obesity or overweight with comorbidities FDA Approval: November 2023 Doses: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg (weekly) Manufacturer: Eli Lilly Cost: $1,069/month Mounjaro: Indication: Type 2 diabetes management FDA Approval: May 2022 Doses: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg (weekly) Manufacturer: Eli Lilly Cost: $1,069/month Note: Identical to Zepbound, prescribed off-label for weight loss Compounded Tirzepatide: Source: FDA-registered compounding pharmacies Indication: Prescribed for weight loss by licensed providers Doses: Custom concentrations available Cost: $349-$699/month Same active ingredient as Zepbound/Mounjaro Why Tirzepatide Is More Effective: Dual Mechanism: GLP-1 Effects (Same as Semaglutide): Appetite suppression through brain receptors Slowed gastric emptying Increased insulin secretion Decreased glucagon production Additional GIP Effects: Enhanced insulin response beyond GLP-1 alone Improved insulin sensitivity in tissues Effects on fat metabolism and energy expenditure Synergistic appetite reduction Additional weight loss mechanisms Result: The combination produces 5-7% more weight loss than GLP-1 agonists alone
On Ozempic, focus on these nutrient-dense foods: Eggs: One of nature's perfect protein packages Fatty fish: Salmon, sardines, and mackerel give you protein plus omega-3s Greek yogurt: High protein, calcium, and probiotics in one Colorful vegetables: Different colors provide different nutrients Nuts and seeds: Small but mighty nutritional powerhouses Berries: Low in calories but packed with antioxidants Foods to limit: When your appetite is reduced, try to avoid "empty calorie" foods that provide little nutritional value: Processed snack foods Sugary drinks White bread and refined grains Alcohol (which can also worsen Ozempic side effects) For a deeper dive into exactly what to eat while on Ozempic, check out my post on Ozempic Diet Plan where I explain the nutrition principles for success on this medication
34 The fluorescently labelled semaglutide (CY3-semaglutide
