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Further, controlled clinical studies simulating NSW provide causal evidence that melatonin secretion diminishes rapidly upon night work exposure and remains suppressed with continued circadian disruption 183

The findings have drawn attention to patterns of experience that could warrant closer clinical scrutiny as use of these therapies expands

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As the use of GLP-1 RA expands, ongoing monitoring of side effects, especially those that are underrecognized in clinical settings, is essential for a better understanding of patient experiences and guiding future studies