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In these trials, it is not clear if mTOR inhibition was achieved in the kidney or whether mTORC1 inhibition triggers a compensatory activation of mTORC2 limiting the beneficial effects of mTORC1 ( AMP-activated protein kinase (AMPK) AMPK is activated under conditions of metabolic and other cellular stresses (Steinberg and Hardie, 2022)
Yu et al., 2012) processes, by different downstream pathways
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One such study with semaglutide (generic drug name for Wegovy) found that on discontinuation of the medication, patients regained about two-thirds of their prior weight loss in just a year.* 2/3 of lost weight regained within one year of stopping semaglutide 2/3 of lost weight regained within one year of stopping semaglutide A similar study tested deprescribing of tirzepatide (generic drug name for Zepbound)
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