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Protein misfolding and aggregation A defining feature of many NDDs is the accumulation of misfolded, aggregation-prone proteins (A and tau in AD, -synuclein in PD, SOD1/TDP-43 in ALS, etc.) [53]

Figure 2 illustrates that CVOTs consistently demonstrate a reduction in major adverse cardiovascular events (MACE) with either GLP-1RA or SGLT2i monotherapy, whereas combination therapy shows a uniform but non-statistically significant reduction

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In cases where the source of the bleed is unclear, but melena is present, an upper endoscopy is recommended, to try to ascertain the source of the bleed