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Those with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasias should not use them

It was first approved for adults with type 2 diabetes to improve glycemic control

22/LO/0045) and was conducted in accordance with the Declaration of Helsinki, the principles of good clinical practice and all applicable regulatory requirements, including the Research Governance Framework and the Medicines for Human Use (Clinical Trial) Regulations 2004 and any subsequent amendments

That said, semaglutide still produces clinically meaningful, life-improving weight loss for the majority of patients