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Common short-term adverse effects observed in Phase 2 trials include nausea, vomiting, diarrhoea, and decreased appetite, consistent with other GLP-1-based therapies

The large number of IGFBPs, IGFBP-rPs as well as other carrier proteins affect bioavailability of IGF-1 in circulation and reduces significantly the levels of immunoreactive IGF-1 in serum samples, requiring multiple pre-treatment steps that reduce reproducibility and complicates interpretation of IGF-1 assay results

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Elizabeth McDonald, a professor of radiology at the University of Pennsylvania, told The Guardian