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(2017) have demonstrated that blockade of selective COX-1 or COX-2 enzymes or non-selective COX-inhibitor indomethacin, reversed most of the therapeutic effects of nesfatin-1 peptide on acetic acid-induced gastric ulcer, while COX-2-blockade was consistently more effective

It also appears to exert a protective effect on the gut-brain axis, reducing symptoms of anxiety and stress-induced damage through modulation of serotonin and dopamine systems

IGEN Non-GMO Tested

In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl glycoside is dodecylmaltoside, tridecylmaltoside, and tetradecylmaltoside