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In mice treated with amoxicillin or ciprofloxacin, depletion of Lactobacillus reuteri (Firmicutes) led to reduced brain and serum GABA, downregulation of GABA-A receptors, and diminished 5-HT and DA, neurochemical changes that coincided with anxiety- and depression-like behaviors (Bibi et al., 2025)
It means there is no established data on how these peptides behave in human pharmacokinetics, what adverse events occur at what frequencies, or what drug interactions are possible
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