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In 1955, Christian de Duve reported on acid phosphatase-positive sac-like particles in rat liver cytoplasm (Novikoff et al., 1956) and later showed acid hydrolases in these organelles, which were subsequently named lysosomes

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It is now universally recommended that an individualized approach for the treatment for T2D, which includes assessment according to the patients age, cognitive ability, diabetes complications, duration of disease, comorbidities, and life expectancy, is key for the successful treatment of T2D, as advocated by all prevailing guidelines [11,12,13]

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