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A global reduction in 5-methylcytosine (5mC) levels, indicative of widespread hypomethylation, has been reported in astrocytes of postmortem AD brains, potentially leading to aberrant gene activation 25
NICE guidelines for weight management emphasise evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, and in appropriate cases, pharmacological treatments (such as orlistat or semaglutide) or bariatric surgery
This therapy is used to treat primarily musculoskeletal injuries such as cruciate ligament injuries, prolapsed intervertebral discs, back pain and osteoarthritis
Distinct functional domains of neurofibromatosis type 1 regulate immediate versus long-term memory formation
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