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Extracellular matrix remodeling in oral submucous fibrosis: its stage-specific modes revealed by immunohistochemistry and in situ hybridization

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175 Mitochondrial dysfunction is a defect in the early stage of PD and mainly includes impairment of the mitochondrial electron transport chain, alterations in mitochondrial morphology and dynamics, mutations in mitochondrial DNA, and anomalies in calcium homeostasis, 176 which are closely related to the PD phenotype