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How clinicians might think about this (risk vs benefit) GLP-1 receptor agonists have benefits that are not small: strong glucose lowering in many patients weight loss benefits in certain populations, cardiovascular risk reduction sometimes improved adherence compared to multiple daily pills because of weekly dosing options So for many patients, the benefit side of the equation is heavy

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doi: 10.3389/fnagi.2026.1729015 Received 20 October 2025 Revised 30 January 2026 Accepted 09 February 2026 Published 27 February 2026 Volume 18 - 2026 Edited by Ashok Kumar, University of Florida, United States Reviewed by Jessica N

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