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Description

M., Reimann, F., & Blottire, H

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The almost immediate degradation of GLP-1 in the body raised the question of the mechanisms involved, and inspired by early studies by the German enzymologist, Mentlein (99), Deacon and Holst identified the enzyme dipeptidyl peptidase 4 as the enzyme responsible for the degradation of GLP-1 in plasma (100) and demonstrated that this could be prevented with inhibitors of the enzyme

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