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Selective degradation of mitochondria by mitophagy

They also produce glucose-dependent insulinotropic peptide (GIP), which has an incretin effect like that of GLP-1, the motility hormones (motilin and serotonin), and other hormones such as secretin (SCT) and GLP-2, which regulate digestion and intestinal homeostasis [13]

10.1007/s12035-017-0839-1 Mol

Healthy beta cells secrete a burst of insulin into the portal circulation at the onset of glucose intake, with approximately 70% of the insulin cleared by the liver and not entering the systemic circulation, whereas subcutaneous insulin enters the systemic circulation with some delay and is removed relatively slowly