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Procyanidins from hawthorn ( Crataegus pinnatifida ) alleviate lipid metabolism disorder via inhibiting insulin resistance and oxidative stress, normalizing the gut microbiota structure and intestinal barrier, and further suppressing hepatic inflammation and lipid accumulation

These findings were accompanied by meaningful improvements in cardiometabolic markers including waist circumference, blood pressure, fasting glucose, HbA1c, insulin levels, and lipid profiles

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Simultaneously, DAG is believed to activate protein kinase C (PKC), a family of enzymes implicated in various cellular functions