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*Disclaimer: Major Players sorted in no particular order Recent Industry Developments March 2023: Novo Nordisk announced headline results from the PIONEER PLUS trial, a phase 3b, 68-week efficacy and safety trial with once-daily oral semaglutide 25 mg and 50 mg versus 14 mg as an add-on to a stable dose of 1-3 oral antidiabetic medicines in people with type 2 diabetes in need of treatment intensification

It is worth noting that COMT is predominantly expressed in glial cells but at very low levels in neurons

Novel drugs intend to avoid or minimize, or at best, intentionally resolve gaps and pitfalls already indicated during the concepts establishment and previous attempts to realize intended tools

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