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Distribution: Lipophilic tetrahydrocannabinol diffuses to adipose tissue, lung, liver, and spleen (62)(63)
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In the SURMOUNT-4 trial, withdrawing tirzepatide after initial weight loss led to weight regain, while continued treatment maintained and extended weight reduction
The non-disease-specific mortality was then adjusted using hazard ratios (HRs) per unit change in BMI, sourced from a study conducted on a large cohort of adults from the UK Clinical Practice Research Datalink (CPRD) database ( N = 3.6 million) [35], to account for the increased mortality associated with overweight and obesity
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