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Read the full study: Effect of intra-articular injection of AOD9604 with or without hyaluronic acid in rabbit osteoarthritis model (Ann Clin Lab Sci 2015)

Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight

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USA , 116 , 9433-9442, doi: Zhang, J., Pavlova, N