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Because the peptide occurs naturally in human plasma (at roughly 200 ng/mL in young adults, declining to approximately 80 ng/mL by age 60), topical supplementation essentially restores youthful local concentrations in treated skin

This represents a pharmaceutical design strategy of creating selectivity through structural modification, providing therapeutic benefits while minimizing unwanted effects

However, BERT models are often pre-trained on external datasets such as MIMIC (medical information mart for intensive care), and studies using MIMIC data tend to focus on common codes, limiting the models ability to predict rare diseases

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