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Similarly, 4-aminobiphenyl, metabolized by hepatic CYP1A2, produces reactive intermediates that form DNA adducts in hepatocytes, increasing the mutational burden [27]

Without sufficient glutathione levels, the body's ability to fight free radicals and detoxify harmful substances may become compromised

Moreover, a detail mechanism can be performed using QM/MM simulation to understand the proton transfer during oxidation of selected flavonoids when interacting through A-ring and B-ring in the presence of blocked or free 3-OH group on the unconjugated C-ring with catechol group

Therefore, if you are pregnant or breastfeeding, it is recommended to discuss it with your doctor before starting any treatment course