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2012) characterised this as still a genuinely controversial issue, acknowledging both the relative rarity of serious adverse events in monitored clinical populations and the legitimate uncertainty about unconstrained off-label long-term use

At 10mg/mL, you get 15 weeks of initiation dosing at 1mg, nearly 8 weeks at 2mg, and almost 4 weeks at the 4mg escalation dose

and MAFFULLI, G.D., 2013

Cancer cells frequently exhibit elevated levels of receptors such as the folate receptor, transferrin receptor, epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER2), and integrins, which can be exploited for receptor-mediated endocytosis