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Stage 2: Following a two-stage sifting strategy against pre-specified criteria, data on reliability and validity are extracted from each included article

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Radiotherapy increases tumor cell ferroptosis susceptibility, significantly inducing the expression of long-chain acyl-CoA synthetase 4 (ACSL4) and the ferroptosis inhibitors SLC7A11 and GPX4, thereby effectively suppressing tumor growth ( Researchers successfully repolarized macrophages from tumor-promoting M2 to anti-tumor M1 phenotype through ferroptosis using MIL88B/RSL3 nanomaterials