Dual GLP-1/GIP receptor agonists, such as tirzepatide, simultaneously activate both receptors, thereby potentiating glycemic control, promoting weight loss, and ameliorating metabolic dysfunction
Other Label Considerations Worth Raising Beyond thyroid-specific issues, the Wegovy label directs attention to acute pancreatitis, acute gallbladder disease, acute kidney injury due to volume depletion, severe gastrointestinal reactions, hypersensitivity reactions, and hypoglycemia when combined with insulin or an insulin secretagogue
This means it has a lower potential for abuse or dependence compared to scheduled or controlled weight-loss drugs like phentermine
Also, the chemical forms of selenium found in food are varied (see Sources) and may have very different biological and toxicological effects (70, 71)