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NPs are addressing this challenge by employing mechanisms such as RMT and AMT to facilitate drug transport across the BBB [201]

We connected the whole body model of acetaminophen metabolism to our previously constructed model of glutathione metabolism[9] so that we could study the depletion of GSH after APAP doses of various sizes (Figure6)

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[2] Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C