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Amyotrophic Lateral Sclerosis and pain: a narrative review from pain assessment to therapy

The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system

McIntosh CHS, Widenmaier S, Kim SJ

Soft tissue and altered biomechanics in patients with a high BMI can make surgical exposure and component placement more challenging, leading to prolonged operative times