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The differences in the prevalence of DR in different ethnic groups may be related to genetic factors (79)

Inclusion Criteria The included studies had to meet the following criteria: Studies that reported the combined use of GLP1-RAs and SGLT2is in individuals with T2D were included if they provided a clear description of the study design and well-defined measurements for any outcome relevant to the research questions

But retatrutides broader receptor engagement produces a stronger metabolic effect within a similar pharmacokinetic window

Conclusion GLP-1 microdosing sits between biological plausibility and clinical uncertainty