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Early foundational biochemical work helped establish GHK as a biologically active copper-binding peptide involved in tissue repair environments: Comprehensive review of GHKs regenerative and matrix-related roles: Unlike synthetic growth factors, GHK is endogenous meaning it naturally occurs in the body which has contributed to long-term scientific interest

The peptide is being developed for topical application, and one additional benefit is that as a small protein, it will be safely broken down into naturally occurring amino acids after exerting its therapeutic effects

Compound 27 (IC 50 = 1.12 nM) was the most promising, exhibiting selectivity for DPP-4 over DPP-8/9