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It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2

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Each 3-capsule daily serving delivers 600 mg of alpha-lipoic acid, 300 mg of benfotiamine, 600 mg of N-acetylcysteine (NAC), and 500 mg of acetyl-L-carnitine (ALCAR) four ingredients commonly studied for their role in reducing neuropathic pain and improving nerve function

For calf cramps, try pointing your toes toward your head while keeping your leg straight