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Subsequent re-analyses and recent studies have challenged the initial interpretations of the WHI findings, suggesting that estrogen-alone therapy or regimens using bioidentical progesterone may present a more favorable safety profile [34,87]

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When injected into the tumor, this strain has been shown to increase the concentration of L-arginine within the microenvironment, leading to increased infiltration of tumor-infiltrating T cells, sustained effector T-cell functions, increased tumor-specific T-cell memory formation, and enhanced efficacy of PD-L1-blocking antibodies

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