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The Relevance of Glutathione Reductase Inhibition by Fluoxetine to Human Health and Disease: Insights Derived from a Combined Kinetic and Docking Study

pRTECs are interconnected by gap junctions and tight junctions, and when ferroptosis occurs in one cell, NADPH can simply diffuse from adjacent cells to the dead cell via cell junctions, thus making the adjacent cells less antioxidant and more sensitive to ferroptosis [101, 102]

The contrasting responses to combined mTORC1 inhibition and ferroptosis induction in different cellular contexts are likely dictated by complex factors including genetic mutation landscape, the ratio of polyunsaturated to monounsaturated phospholipids, iron availability, the basal activities of the PI3K/mTORC1 pathway, and the overall cellular redox state

Supports better vaccine or immune challenge responses, especially in older adults