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The article says appetite hormones normalize rapidly and metabolic adaptations reverse when therapy stops

Interestingly, insulin is a common factor that activates Na + /K + -ATPase and increases its expression while also lowering blood glucose, consistent with DEN therapy

doi: 10.1111/liv.16150, 6

Each compound was supplemented to culture media at a concentration of 100 M and 10 g ml 1 tetracycline (Tc) was used as a positive control for bacterial growth inhibition