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A Novo Nordisk spokesperson called out how NAION is not listed on approved labels as an adverse drug reaction for the marketed formulations of semaglutide. They also highlighted limitations of the Mass Eye and Ear study, such as how the sample group was small and not randomized

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Crucially, their ability to reduce hepatocyte stress and injury may create a microenvironment more conducive to immune surveillance and tumor suppression, potentially enhancing endogenous mechanisms of cancer control